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KMID : 0869619960130030228
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Journal of Korean Society of Hospital Pharmacists
1996 Volume.13 No. 3 p.228 ~ p.231
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The Acid Resistance, Dissolution test and Content Uniformity test of Omeprazole tablets by HPLC
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노지연/Roh, Ji Yeon
조하령/전정미/임동수/최승기/Cho, Ha Ryung/Jeon, Jeong Mi/Yim, Dong Soo/Choi, Seung ki
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Abstract
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Drug effect is depended on bioavailability of preparation and bioavailability is largely depended on dissolution rate and content uniformity. This study was attempted to evaluate bioavailability of preparations for drug selection by conducting the dissolution test, acid resistance and content uniformity test on commercial omeprazole tablets. The dissolution test and acid resistance were comducted in artificial gastric juice and artificial intestinal juice using K.P 2 method with three omeprazole preparations(A, B and C) which were pharmaceutically equivalent. The result as following: 1) Acid resistance in artificial gastric juice was C>B>A, 2) The dissolution rate in artificial intestinal juice at 30 min in the three different brands were C>B>A, 3) Content uniformity of three different brands was in such order as B>A>C, 4) There was no relationship between acid resistance, dissolution rate and content uniformity.
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KEYWORD
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